New Orleans Saints vs Buffalo Bills 2025 Week 4 Preview

Caleb Yaccarino • September 27, 2025

The losing streak is up to three games, and after last week's horrible loss to the Seahawks, the Saints aim to bounce back in Week 4. Only issue is their opponent... the Buffalo Bills.

What the Bills bring to the table

Entering this game 3-0, the Bills are one of, if not the best, team in the NFL. A Super Bowl is more of an expectation than a hope with this team, with star QB Josh Allen leading the team. There is not much a team can do against the Bills high-power offense, and that's primarly due to Allen's ability to dominate. If you play off, he will pick apart the defense; if you send pressure, he will avoid it and make the play; and if you cover everything, he will beat you on the run. The Bills rushing attack is also excellent, with James Cook having a great year so far. On defense, the Bills pass rush has been decent so far, and the run defense could be exposed at times. The pass defense has also struggled this year, and could be another issue going into the game.

How about the Saints?

Yeah, this could be a tough one. The Saints have had some good moments throughout the season so far, but last week was horrible, and could be a sign for things to come in this game. This defense is not ready to compete in the NFL, and teams will be able to pick them apart. The pass rush has been underwhelming, and the pass defense has been horrible. This is a recipe for Josh Allen to do anything he wants against the Saints. On offense, QB Spencer Rattler has been decent and could win games, the rushing attack has looked strong, and when healthy, the offensive line is good. The issue is consistency with this group and penalties. Special teams also need to be much better, and if kicker Blake Grupe misses another makeable kick, I'm not sure he will be on the team after this game.

Injury Report

  • EDGE Chase Young - OUT
  • WR Devaughn Vele - Questionable
  • G Dillon Radunz - OUT

My Prediction

I love being optimistic going into each game, but there is zero chance I can feel comfortable about the Saints against the Bills. I can almost guarantee this game results in a Saints loss, and I have the final score at 38-14, with the Bills dominating for most of the game.


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