New Orleans Saints vs San Francisco 49ers 2025 Week 2 Preview

Caleb Yaccarino • September 14, 2025

After a close loss to the Arizona Cardinals, the New Orleans Saints have a chance to bounce back against a depleted San Francisco 49ers team, but can they do it?


What the 49ers bring to the table

Going into each season, the 49ers are a competitive team filled with talent, but this year is a bit different. The team saw many key players leave this offseason, and with the goal of extending QB Brock Purdy's contract, many of the roster holes could not be filled. In addition, injuries have been a constant issue for the 49ers, and this year as already started with way too many. Purdy will be out of this game, which leaves backup Mac Jones set to start. With RB Christian McCaffrey healthy, the game plan should be to rely on the running game. If they do go to the pass, 2nd-year WR Ricky Pearsall and veteran Juan Jennings will be the main targets in the offense. Going to the defensive side of the ball, this is where the 49ers can win this game.  With Nick Bosa on the edge, Fred Warner at LB, and Deommodore Lenoir at CB, the Saints are going to have a tough matchup ahead of them.


How about the Saints?

After their loss to the Cardinals, the Saints had some positives to take away from the game. Spencer Rattler looked fine passing and was accurate, the running game looked excellent, the offensive line did not struggle much, and the defensive line disrupted the game. The main issues were the penalties, and if the Saints have any hope of winning this game, they need to fix that. This is also a game Rattler should do well in. Yes, I mentioned the defense for the 49ers is strong, but Rattler is going to have opportunities to throw deep on this team, and he could have a big game.


Injury Report

  • EDGE Chase Young - OUT
  • G Trevor Penning - OUT
  • S Jordan Howden - Questionable


My Prediction

I believe if Spencer Rattler plays well in this game, the New Orleans Saints win. I think this happens, and the Saints should also clean up the penalties. My final score prediction is 24-10 with the Saints winning.





A quick share helps us a lot!

By Kaden Arkeder September 11, 2026
It is week one folks, we made it to the 2026 season! This is the first season in a while where personally I feel optimistic going into the season thanks to Tyler Shough and what the Saints were able to show at the end of the 2025 season. Coupled with what the Saints did in the offseason in free agency and the draft the Saints and Saints fans should feel like the team has a real shot at winning the division and making the playoffs. Their first obstacle they will have to overcome on their path to accomplishing the goal is the Detroit Lions. The Lions will prove to be a good litmus test for the Saints in week one. The Lions have been a championship contender the last few years under the stewardship of Dan Campbell and will look to continue their fortune by taking care of business at home against the Saints. The Saints however are not facing the Lions at their peak as they finished last season with a 9-8 win loss record after being a double digit win team the two prior seasons. The Lions will also not have at least two key players in their secondary as both Brian Branch and Kerby Joseph are on injured reserve while two of their corners are on the injury report albeit listed as full participants as I am writing this. So the Saints will look to capitalize through the passing game with those key players out for this matchup. I expect Chris Olave to be targeted early and often in this game and for the role players around him to come up big on some key plays throughout the game. Speaking of role players I am curious to see if either or both of the rookie receivers in Barion Brown and Bryce Lance have any big moments in the game after having a great offseason and preseason. Outside of the rookie receivers I am curious to see if Juwan Johnson will be able to build on the productive season he had last year. With the absence of Jordyn Tyson to begin the season there should be plenty of opportunity for targets in the passing game outside of Chris Olave’s share. In regards to the running game I expect the Saints to give Etienne a heavy workload against the Lions if Kamara is not active for the game but there is optimism Kamara is ahead of schedule and could play against the Lions. I will be very interested to see how Etienne does in his debut with the team and how he will be utilized in the offense. There was talk during training camp the Saints have a package with both Etienne and Kamara on the field so if both are active I will be keeping an eye out for that personnel package. The Saints will look to start off the season strong on the ground after being one of the least effective teams running the ball last season. Hopefully the addition of David Edwards and Etienne combined with Kellen Moore along with most of the players being in year two of Kellen Moore’s system will aid them in running the ball better this season. Adin Hutchinson will look to be the main challenge the offensive line will face against the Lions defensive line as he had a standout 2025 campaign with 14.5 sacks along with an interception. If the Saints young tackles in Kelvin Banks and Taliese Fuaga are able to hold up well against Hutchinson they should be able to hold up well against the best edge rushers for the rest of the season. On the defensive side of the ball this will be very much a good challenge for them as the Lions have some marquee players on offense the defense will be tasked with slowing down. Amon Ra St. Brown and Jhamyr Gibbs are the two skill position players to key in on for the Saints in this game but role players like Sam LaPorta and Jameson Williams can absolutely be a difference maker for the Lions on any given Sunday. I think my two favorite matchups on this side of the ball will be watching Chase Young against Penei Sewell and the Saints young secondary against Amon Ra St. Brown. Chase Young had ten sacks in twelve games last season and will look to continue this success against one of the league’s best tackles in Penei Sewell. Unfortunately his running mate in Cameron Jordan will be unavailable in this game so look for a steady rotation at edge opposite of Chase Young throughout the game. Amon Ra St. Brown is the type of receiver Jared Goff looks for early and often throughout the game and can be moved around their offensive formations even though he plays primarily in the slot. How the Saints plan to contain or slow down Amon Ra will be fascinating to watch. Overall, I expect this to be a close game between the Saints and Lions where both teams should have ample opportunities to put up points against each other. There are so many little story lines to follow as the Saints start the regular season and in this game I can’t wait to follow. Week one usually has a fair amount of chaos to the games so you can never discount a crazy outcome here or elsewhere throughout the league. There should be plenty to discuss coming out of week one. Alright enough from me, talk to you all on the other side and geaux Saints! Injury Designations Lions DB - Christian Izien - Questionable Saints TE - Oscar Delp - OUT Edge - Cameron Jordan - OUT RB - Audric Estime - OUT RB - Alvin Kamara - Questionable
By Dusty Thibodeaux September 11, 2026
ULM enters the Saturday afternoon game +9.5 to UAB
Show More