New Orleans Saints vs Arizona Cardinals 2025 Week 1 Preview

Caleb Yaccarino • September 6, 2025

The NFL Regular season is here, and so is the new era of New Orleans Saints football. Led by new head coach Kellen Moore, the Saints host the Arizona Cardinals in a Week 1 matchup that both teams need to take advantage of.

What the Cardinals bring to the table

As this is the first game for both teams this season, we may not see the full potential of each squad, but we can pinpoint the strengths and weaknesses of the Cardinals on paper. Starting with the strengths that may make the Saints' lives difficult on Sunday, we need to talk about Kyler Murray. The 7th-year QB is a dynamic runner who could take over games with just his speed. Being able to stop Murray from running for positive yards is one thing, but also trying to contain him and not extend plays is nearly impossible, and with edge rusher Chase Young ruled out, the Saints are going to have a real challenge on Sunday. On the defensive side of the ball, the Cardinals have made significant improvements to their defensive line, and this will be a good first test for the Saints' newly constructed defensive line. Josh Sweat is the main name to point out, and if New Orleans can not deal with him, he could disrupt any offensive plan Kellen Moore has.


These are two strengths that jump out, but the Cardinals also have some weaknesses that the Saints can take advantage of. Like with New Orleans, Arizona has a very young/inexperienced cornerback room. The run game is going to be a focal point of the Saints' offense, but if that slows down or the Saints are behind early, starting QB Spencer Rattler could take advantage of the Cardinals' cornerbacks. The other main weakness is the offensive line. Last season, led by OL coach Klayton Adams, the offensive line overperformed and was a solid group throughout the season. Now, with him leaving for the Dallas Cowboys, this group could take a step back, and even without Chase Young, the Saints can still disrupt the game through the defensive line.

How about the Saints?

I mentioned before in the intro that this is a new era of Saints football. With an entirely new coaching staff and new players throughout the roster, there is way too much uncertainty to really feel comfortable about this game. Besides the WR room led by Chris Olave and Rashid Shaheed, the safety room led by Justin Reid, and the Center position with Eric McCoy, every other spot on the roster is going to be tested this Sunday. The primary position of focus for everyone is at quarterback, with all eyes on second-year QB Spencer Rattler. After beating out second-round rookie Tyler Shough in a heated QB battle, Rattler was named the starter and overcame the odds. Kellen Moore has stated multiple times before the decision was made that the team would rally behind whoever he and his staff decided to name the starter. This is the case.... for now. QB Tyler Shough is Kellen Moore's "guy," and he will be ready to come in if need be. Will that happen this game? I highly doubt it, but the Saints' coaching staff will evaluate Rattler's performances each week and consider putting in Shough if the team starts to lose. This is just one of the outcomes, and Spencer Rattler can still secure the long-term starting QB spot,. However, against the Cardinals, the pressure will be on Rattler to perform.

Injury Report

  • EDGE Chase Young - OUT
  • G Trevor Penning - OUT
  • S Jordan Howden - Questionable

My Prediction

Even after mentioning all the uncertainty with the Saints in this game, especially at QB, I think New Orleans will win this game 20-17, with Blake Grupe hitting a game-winning field goal.

A quick share helps us a lot!

Saints Pregame Guide: Lions

By Kaden Arkeder • September 11, 2026
It is week one folks, we made it to the 2026 season! This is the first season in a while where personally I feel optimistic going into the season thanks to Tyler Shough and what the Saints were able to show at the end of the 2025 season. Coupled with what the Saints did in the offseason in free agency and the draft the Saints and Saints fans should feel like the team has a real shot at winning the division and making the playoffs. Their first obstacle they will have to overcome on their path to accomplishing the goal is the Detroit Lions. The Lions will prove to be a good litmus test for the Saints in week one. The Lions have been a championship contender the last few years under the stewardship of Dan Campbell and will look to continue their fortune by taking care of business at home against the Saints. The Saints however are not facing the Lions at their peak as they finished last season with a 9-8 win loss record after being a double digit win team the two prior seasons. The Lions will also not have at least two key players in their secondary as both Brian Branch and Kerby Joseph are on injured reserve while two of their corners are on the injury report albeit listed as full participants as I am writing this. So the Saints will look to capitalize through the passing game with those key players out for this matchup. I expect Chris Olave to be targeted early and often in this game and for the role players around him to come up big on some key plays throughout the game. Speaking of role players I am curious to see if either or both of the rookie receivers in Barion Brown and Bryce Lance have any big moments in the game after having a great offseason and preseason. Outside of the rookie receivers I am curious to see if Juwan Johnson will be able to build on the productive season he had last year. With the absence of Jordyn Tyson to begin the season there should be plenty of opportunity for targets in the passing game outside of Chris Olave’s share. In regards to the running game I expect the Saints to give Etienne a heavy workload against the Lions if Kamara is not active for the game but there is optimism Kamara is ahead of schedule and could play against the Lions. I will be very interested to see how Etienne does in his debut with the team and how he will be utilized in the offense. There was talk during training camp the Saints have a package with both Etienne and Kamara on the field so if both are active I will be keeping an eye out for that personnel package. The Saints will look to start off the season strong on the ground after being one of the least effective teams running the ball last season. Hopefully the addition of David Edwards and Etienne combined with Kellen Moore along with most of the players being in year two of Kellen Moore’s system will aid them in running the ball better this season. Adin Hutchinson will look to be the main challenge the offensive line will face against the Lions defensive line as he had a standout 2025 campaign with 14.5 sacks along with an interception. If the Saints young tackles in Kelvin Banks and Taliese Fuaga are able to hold up well against Hutchinson they should be able to hold up well against the best edge rushers for the rest of the season. On the defensive side of the ball this will be very much a good challenge for them as the Lions have some marquee players on offense the defense will be tasked with slowing down. Amon Ra St. Brown and Jhamyr Gibbs are the two skill position players to key in on for the Saints in this game but role players like Sam LaPorta and Jameson Williams can absolutely be a difference maker for the Lions on any given Sunday. I think my two favorite matchups on this side of the ball will be watching Chase Young against Penei Sewell and the Saints young secondary against Amon Ra St. Brown. Chase Young had ten sacks in twelve games last season and will look to continue this success against one of the league’s best tackles in Penei Sewell. Unfortunately his running mate in Cameron Jordan will be unavailable in this game so look for a steady rotation at edge opposite of Chase Young throughout the game. Amon Ra St. Brown is the type of receiver Jared Goff looks for early and often throughout the game and can be moved around their offensive formations even though he plays primarily in the slot. How the Saints plan to contain or slow down Amon Ra will be fascinating to watch. Overall, I expect this to be a close game between the Saints and Lions where both teams should have ample opportunities to put up points against each other. There are so many little story lines to follow as the Saints start the regular season and in this game I can’t wait to follow. Week one usually has a fair amount of chaos to the games so you can never discount a crazy outcome here or elsewhere throughout the league. There should be plenty to discuss coming out of week one. Alright enough from me, talk to you all on the other side and geaux Saints! Injury Designations Lions DB - Christian Izien - Questionable Saints TE - Oscar Delp - OUT Edge - Cameron Jordan - OUT RB - Audric Estime - OUT RB - Alvin Kamara - Questionable

Personal game for Vincent's Warhawks

By Dusty Thibodeaux • September 11, 2026
ULM enters the Saturday afternoon game +9.5 to UAB
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